(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

Base Information

Chemical Name:(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline
CAS No.:409319-30-8
Molecular Formula:C₁₉H₁₈F₃NO₃S
Molecular Weight:397.418
Hs Code.:

Synonyms:(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

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Chemical Property of (6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

Chemical Property:

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Technology Process of (6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

There total 3 articles about (6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 409319-29-5
(6R,8R)-(+)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-hydroxyphenyl)-6,8-methanoquinoline

: 409319-30-8
(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(01)01002-X

Reference yield:

: 1-<2-(2-Methoxyphenyl)-2-oxyethyl>pyridinium iodide

: 409319-30-8
(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 24 percent / ammonium acetate / acetic acid / 20 h / 120 °C

2: 95 percent / BBr₃ / CH₂Cl₂ / 0 - 20 °C

3: 82 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; ammonium acetate; boron tribromide; In dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)01002-X

Reference yield:

: 409319-28-4
(6R,8R)-(+)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-methoxyphenyl)-6,8-methanoquinoline

: 409319-30-8
(6R,8R)-5,6,7,8-tetrahydro-7,7-dimethyl-2-(2-trifluoromethanesulfonyloxy)-6,8-methanoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / BBr₃ / CH₂Cl₂ / 0 - 20 °C

2: 82 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; boron tribromide; In dichloromethane;
DOI:10.1016/S0040-4020(01)01002-X