Methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate

Base Information

• Chemical Name: Methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate
• CAS No.: 6636-50-6
• Molecular Formula: C21H24O6
• Molecular Weight: 372.4117
• NSC Number: 51557
• DSSTox Substance ID: DTXSID80287554
• Mol file: 6636-50-6.mol

Synonyms:6636-50-6;methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate;NSC51557;DTXSID80287554;NSC-51557

Chemical Property of Methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate

Chemical Property:

• Vapor Pressure: 3.17E-11mmHg at 25°C
• Boiling Point: 510°Cat760mmHg
• Flash Point: 175.6°C
• Density: 1.227g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 372.15728848
• Heavy Atom Count: 27
• Complexity: 577

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCC2=C(C1(CC(=O)OC)O)C=CC3=C2C=C(C=C3)OC)C(=O)OC

Technology Process of Methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate

There total 1 articles about Methyl 1-hydroxy-6-methoxy-1-(2-methoxy-2-oxoethyl)-2-methyl-1,2,3,4-tetrahydrophenanthrene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-phenanthrene-2-carboxylic acid methyl ester (7471-38-7) + bromoacetic acid methyl ester (96-32-2) → (1-hydroxy-6-methoxy-2-methoxycarbonyl-2-methyl-1,2,3,4-tetrahydro-[1]phenanthryl)-acetic acid methyl ester (6636-50-6)

Guidance literature:

With zinc;

DOI:10.1021/ja01193a014

Reference yield:

(1-hydroxy-6-methoxy-2-methoxycarbonyl-2-methyl-1,2,3,4-tetrahydro-[1]phenanthryl)-acetic acid methyl ester (6636-50-6) → (2-carboxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]phenanthryl)-acetic acid (7471-40-1,6636-46-0)

Guidance literature:

With pyridine; thionyl chloride; benzene; anschliessendes Erwaermen des Reaktionsprodukts mit methanol. Kalilauge und Schuetteln einer Loesung der erhaltenen Saeure in Wasser mit Natrium-Amalgam; Reinigung ueber den Dimethylester;

DOI:10.1021/ja01193a014

upstream raw materials:

6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-phenanthrene-2-carboxylic acid methyl ester

bromoacetic acid methyl ester

Downstream raw materials:

(2-carboxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]phenanthryl)-acetic acid