4-(Pyridin-2-yloxy)aniline

Base Information

• Chemical Name: 4-(Pyridin-2-yloxy)aniline
• CAS No.: 76471-08-4
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.213
• European Community (EC) Number: 856-753-8
• Mol file: 76471-08-4.mol

Synonyms:4-(pyridin-2-yloxy)aniline;76471-08-4;4-(Pyridin-2-yloxy)phenylamine;4-(2-pyridyloxy)aniline;4-pyridin-2-yloxyaniline;MFCD06825428;SCHEMBL4379584;RTGVTQOURHFJEO-UHFFFAOYSA-N;AKOS000577203;LS-11226;SY192183;EN300-71835;E87733;Z404011946

Chemical Property of 4-(Pyridin-2-yloxy)aniline

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

4-(pyridin-2-yloxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)OC2=CC=C(C=C2)N

Technology Process of 4-(Pyridin-2-yloxy)aniline

There total 7 articles about 4-(Pyridin-2-yloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-fluoropyridine (372-48-5) + 4-amino-phenol (123-30-8) → 4-(pyridin-2-yloxy)-phenylamine (76471-08-4)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 16h;

DOI:10.1021/jm401234w

Reference yield: 60.2%

→ 4-(pyridin-2-yloxy)-phenylamine (76471-08-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 20h; Inert atmosphere;

Reference yield: 55.0%

2-iodopyridine (5029-67-4) + 4-amino-phenol (123-30-8) → 4-(pyridin-2-yloxy)-phenylamine (76471-08-4)

Guidance literature:

With copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In propyl cyanide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja9081815

upstream raw materials:

2-<(4-nitrophenyl)oxy>pyridine

2-bromo-pyridine

4-amino-phenol

2-iodopyridine

Downstream raw materials:

N-(4-(pyridin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine

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