N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Base Information

Chemical Name:N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide
CAS No.:1241566-74-4
Molecular Formula:C₂₅H₁₆F₃N₅O₂S
Molecular Weight:507.496
Hs Code.:

Synonyms:N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

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Chemical Property of N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

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Technology Process of N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

There total 4 articles about N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 1258381-12-2
C₁₆H₉N₄OS^(1-)*K⁽¹⁺⁾

: 351-38-2
N-chloroacetyl-3-(trifluoromethyl)aniline

: 1241566-74-4
N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: In isopropyl alcohol; for 1 - 1.5h; Reflux;
DOI:10.1007/s00044-012-0257-x

Reference yield: 90.5%

: 1258381-18-8
C₁₈H₁₂N₄O₃S

: 98-16-8
3-trifluoromethylaniline

: 1241566-74-4
N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: C₁₈H₁₂N₄O₃S; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; at 60 - 80 ℃; for 1h; Reflux;

3-trifluoromethylaniline; In 1,4-dioxane; for 3 - 6h; Reflux;
DOI:10.1007/s00044-012-0257-x

Reference yield:

: 1258381-18-8
C₁₈H₁₂N₄O₃S

: 1241566-74-4
N-(3-trifluorophenyl)-2-[(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1,4-dioxane / 60 - 80 °C

2: 1,4-dioxane / 3 - 6 h / Reflux

With thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane;
DOI:10.1007/s00044-012-0257-x