2-iodo-4,5-dimethylbenzaldehyde

Base Information

• Chemical Name: 2-iodo-4,5-dimethylbenzaldehyde
• CAS No.: 1094026-85-3
• Molecular Formula: C₉H₉IO
• Molecular Weight: 260.074
• Mol file: 1094026-85-3.mol

Synonyms:2-iodo-4,5-dimethylbenzaldehyde

Chemical Property of 2-iodo-4,5-dimethylbenzaldehyde

Chemical Property:

• Melting Point: 83-87°C
• Boiling Point: 300.5±30.0 °C(Predicted)
• Density: 1.670±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-Iodo-4,5-dimethylbenzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-iodo-4,5-dimethylbenzaldehyde

There total 4 articles about 2-iodo-4,5-dimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-iodo-4,5-dimethylphenyl)methanol (851384-78-6) → 2-iodo-4,5-dimethylbenzaldehyde (1094026-85-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00752

Reference yield:

2-iodo-4,5-dimethylbenzoic acid (35149-23-6) → 2-iodo-4,5-dimethylbenzaldehyde (1094026-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / 5 h / 0 - 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 12 h / 20 °C / Inert atmosphere

With borane-THF; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/acs.orglett.6b00752

Reference yield:

2-amino-4,5-dimethylbenzoic acid (15089-51-7) → 2-iodo-4,5-dimethylbenzaldehyde (1094026-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: hydrogenchloride / water / 0.33 h

2.2: 0.5 h / -4 °C / Cooling with ice

2.3: 1.75 h / 20 - 60 °C

3.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; silica gel; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jacs.8b05743

upstream raw materials:

(2-iodo-4,5-dimethylphenyl)methanol

2-iodo-4,5-dimethylbenzoic acid

2-amino-4,5-dimethylbenzoic acid

Downstream raw materials:

2-iodo-4,5-dimethylbenzoic acid