6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Name:6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1221501-68-3
Molecular Formula:C₂₆H₂₂FN₃O₂
Molecular Weight:427.478
Hs Code.:

Synonyms:6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 8 articles about 6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943994-02-3
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

: 1221504-06-8
4-bromo-5-(4-fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazole

: 1221501-68-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

: 180462-77-5
tert-butyl-2-[(4-methylphenyl)methylidene]hydrazinecarboxylate

: 1221501-68-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / water / 2 h / 20 °C

2: dichloromethane / 20 °C

3: triethylamine; trifluoroacetic acid / isopropyl alcohol / 2 h / 80 °C

4: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

5: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With N-Bromosuccinimide; sodium cyanoborohydride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1221504-05-7
5-(4-fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazole

: 1221501-68-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(4-methylbenzyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With N-Bromosuccinimide; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetonitrile;