{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

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Chemical Name:{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone
CAS No.:1215850-04-6
Molecular Formula:C₂₂H₁₈F₃N₅O₂S
Molecular Weight:473.478
Hs Code.:

Synonyms:{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

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Chemical Property of {5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

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Technology Process of {5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

There total 5 articles about {5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 14542-12-2
(1,3-thiazol-2-yl)methanol

: 1215850-29-5
[5-(6-chloropyridazin-3-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoromethylphenyl)methanone

: 1215850-04-6
{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

Guidance literature:: (1,3-thiazol-2-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

[5-(6-chloropyridazin-3-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoromethylphenyl)methanone; In N,N-dimethyl-formamide; mineral oil; at 150 ℃; for 30h;

Reference yield:

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 1215850-04-6
{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

2.1: 3 h / 20 °C

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

3.2: 100 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

4.2: 30 h / 150 °C

With potassium tert-butylate; sodium hydride; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: (3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate

: 1215850-04-6
{5-[6-(thiazol-2-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one

1.2: 100 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 30 h / 150 °C

With potassium tert-butylate; sodium hydride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; mineral oil;