(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
CAS No.:142592-30-1
Molecular Formula:C₂₄H₃₁NO₆S
Molecular Weight:461.579
Hs Code.:

Synonyms:(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

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Technology Process of (-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

There total 3 articles about (-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 699-12-7
2-(phenylthio)ethanol

: 141600-64-8
(+)-1,4-dihydro-2,4,6-trimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

: 142592-30-1
(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.1083

Reference yield:

: 141600-97-7
1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid

: 142592-30-1
(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 0 deg C, 8 h

2: 76 percent / lipase H, H₂O / diisopropyl ether / 8 h / Ambient temperature

3: 1.) SOCl₂, DMF / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, 0 deg C, 1 h

With thionyl chloride; lipase H; water; sodium hydride; N,N-dimethyl-formamide; In di-isopropyl ether;
DOI:10.1248/cpb.45.863

Reference yield:

: 141600-63-7
1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid pivaloyloxymethyl ester

: 142592-30-1
(-)-2-(phenylthio)ethanol pivaloyloxymethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / lipase H, H₂O / diisopropyl ether / 8 h / Ambient temperature

2: 1.) SOCl₂, DMF / 1.) CH₂Cl₂, 1 h, 2.) CH₂Cl₂, 0 deg C, 1 h

With thionyl chloride; lipase H; water; N,N-dimethyl-formamide; In di-isopropyl ether;
DOI:10.1248/cpb.45.863