Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester
CAS No.:182494-72-0
Molecular Formula:C₁₉H₂₅N₃O₅Si
Molecular Weight:403.51
Hs Code.:

Synonyms:Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Chemical Property of Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Technology Process of Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

There total 1 articles about Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 81353-38-0
(trimethylsilylethynyl)tributyltin

: 182494-71-9
5-iodo-1-(5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carbonitrile

: 182494-72-0
Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: With bis(benzonitrile)palladium(II) dichloride; In acetonitrile; at 100 ℃; for 10h;
DOI:10.1002/(SICI)1099-1344(199609)38:9<809::AID-JLCR899>3.0.CO;2-0

Reference yield:

: 182494-72-0
Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 182494-74-2
1-[(3aR,4R,6R,6aR)-6-(1,3-Diphenyl-imidazolidin-2-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-5-ethynyl-1H-imidazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / NH₃ / methanol / 2 h / 25 °C

2: 1,3-dicyclohexylcarbodiimide, dichloroacetic acid, oxalic acid / dimethylsulfoxide / 1.5 h / 25 °C

3: methanol / 0.67 h / 25 °C

With dichloro-acetic acid; ammonia; oxalic acid; dicyclohexyl-carbodiimide; In methanol; dimethyl sulfoxide;
DOI:10.1002/(SICI)1099-1344(199609)38:9<809::AID-JLCR899>3.0.CO;2-0

Reference yield:

: 182494-72-0
Acetic acid (3aR,4R,6R,6aR)-6-(4-cyano-5-trimethylsilanylethynyl-imidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 182494-75-3
1-[(3aR,4R,6R,6aR)-6-(1,3-Diphenyl-imidazolidin-2-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-5-ethynyl-1H-imidazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / NH₃ / methanol / 2 h / 25 °C

2: 1,3-dicyclohexylcarbodiimide, dichloroacetic acid, oxalic acid / dimethylsulfoxide / 1.5 h / 25 °C

3: methanol / 0.67 h / 25 °C

4: 78 percent / NH₄OH, 30percent H₂O₂ / methanol / 7 h / 25 °C

With dichloro-acetic acid; ammonium hydroxide; ammonia; dihydrogen peroxide; oxalic acid; dicyclohexyl-carbodiimide; In methanol; dimethyl sulfoxide;
DOI:10.1002/(SICI)1099-1344(199609)38:9<809::AID-JLCR899>3.0.CO;2-0