(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

Base Information

Chemical Name:(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol
CAS No.:178378-13-7
Molecular Formula:C₂₁H₃₂N₂O₂
Molecular Weight:344.497
Hs Code.:

Synonyms:(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

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Chemical Property of (1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

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Technology Process of (1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

There total 8 articles about (1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21894-84-8
2-(aminooxy)-N,N-dimethylethanamine

: 178379-52-7
(1S,3aS,5S,7aR)-3a-hydroxy-5-phenyl-7a-methylperhydroindene-1-carboxaldehyde

: 178378-13-7
(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

Guidance literature:: With hydrogenchloride; sodium acetate; In 1,4-dioxane; at 20 ℃; for 1h; pH=4.5;
DOI:10.1021/jm011001k

Reference yield:

: 591-51-5
phenyllithium

: 178378-13-7
(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C

2: 82 percent / Raney-Ni / ethanol; H₂O / 3 h / Heating

3: 100 percent / IBX / dimethylsulfoxide / 1.5 h

4: NaOAc; aq. HCl / dioxane / 1 h / 20 °C / pH 4.5

With hydrogenchloride; sodium acetate; nickel; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; water; dimethyl sulfoxide;
DOI:10.1021/jm011001k

Reference yield:

: 178379-39-0
(1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone

: 178378-13-7
(1S,3AS,5S,7AR)-1-[(E)-2-dimethylaminoethoxyimino]methyl-5-phenyl-7a-methylperhydroinden-3a-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h / -78 - 0 °C

2: 82 percent / Raney-Ni / ethanol; H₂O / 3 h / Heating

3: 100 percent / IBX / dimethylsulfoxide / 1.5 h

4: NaOAc; aq. HCl / dioxane / 1 h / 20 °C / pH 4.5

With hydrogenchloride; sodium acetate; nickel; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; water; dimethyl sulfoxide;
DOI:10.1021/jm011001k