N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Base Information

Chemical Name:N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
CAS No.:1467093-03-3
Molecular Formula:C₂₉H₂₄FN₇O
Molecular Weight:505.554
Hs Code.:
Mol file:1467093-03-3.mol

Synonyms:N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Suppliers and Price of N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Adavivint >98%
1 g
$ 3200.00

DC Chemicals
Adavivint >98%
100 mg
$ 850.00

CSNpharm
Adavivint
100mg
$ 698.00

CSNpharm
Adavivint
5mg
$ 93.00

CSNpharm
Adavivint
1mg
$ 62.00

ChemScene
Adavivint 99.12%
5mg
$ 100.00

ChemScene
Adavivint 99.12%
10mg
$ 150.00

ChemScene
Adavivint 99.12%
25mg
$ 250.00

ChemScene
Adavivint 99.12%
50mg
$ 450.00

ChemScene
Adavivint 99.12%
100mg
$ 750.00

Total 13 raw suppliers

Chemical Property of N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Chemical Property:

PKA:7.75±0.40(Predicted)
Density:1.365±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Adavivint >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

There total 5 articles about N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1-trityl-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

: 1467093-03-3
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 2.2h;

Reference yield:

: C₂₇H₁₉BrN₂O

: 1467093-03-3
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere

2.1: potassium phosphate monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 17 - 95 °C / Inert atmosphere

2.2: 1 h

3.1: sodium sulfite / 1-methyl-pyrrolidin-2-one / 24 h / 110 - 115 °C

4.1: trifluoroacetic acid / 2.2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium phosphate monohydrate; potassium acetate; trifluoroacetic acid; sodium sulfite; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; 1.1: |Suzuki-Miyaura Coupling;

Reference yield:

: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazole-3-carbaldehyde

: 1467093-03-3
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 17 - 95 °C / Inert atmosphere

1.2: 1 h

2.1: sodium sulfite / 1-methyl-pyrrolidin-2-one / 24 h / 110 - 115 °C

3.1: trifluoroacetic acid / 2.2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate monohydrate; trifluoroacetic acid; sodium sulfite; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;