trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

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Chemical Name:trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid
CAS No.:1443020-64-1
Molecular Formula:C₃₁H₃₇ClN₂O₅S
Molecular Weight:585.164
Hs Code.:

Synonyms:trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

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Chemical Property of trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

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Technology Process of trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

There total 5 articles about trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₉ClN₂O₄S

: 1443020-64-1
trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃; for 3h;
DOI:10.1016/j.bmcl.2016.10.035

Reference yield:

: 812695-59-3,945950-78-7
(S)-5-chloroindan-1-ylamine

: 1443020-64-1
trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 24 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

3: hydrogenchloride; water / 1,4-dioxane / 3 h / 60 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2016.10.035

Reference yield:

: 4-{[2-(2,5-dioxopyrrolidin-1-yl)ethyl]sulfanyl}-3-methylbenzaldehyde

: 1443020-64-1
trans-4-[(((S)-5-chloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethylsulfanyl]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 24 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

3: hydrogenchloride; water / 1,4-dioxane / 3 h / 60 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2016.10.035