6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

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Chemical Name:6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide
CAS No.:1215222-08-4
Molecular Formula:C₂₃H₂₂F₃N₇OS
Molecular Weight:501.535
Hs Code.:

Synonyms:6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

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Chemical Property of 6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

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Technology Process of 6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

There total 6 articles about 6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1215221-90-1
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-thieno[2,3-d]pyrimidine-2-carboxylic acid

: 100-46-9
benzylamine

: 1215222-08-4
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 1215221-89-8
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester

: 1215222-08-4
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

1.2: pH 3

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With water; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 110-62-3
pentanal

: 1215222-08-4
6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)thieno[2,3-d]pyrimidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; sulfur / N,N-dimethyl-formamide / 50 °C

2.1: hydrogenchloride / 1,4-dioxane / 16 h / 0 - 20 °C

3.1: trichlorophosphate / 16 h / Reflux

4.1: triethylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

5.2: pH 3

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; water; sulfur; triethylamine; HATU; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;