N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Base Information

Chemical Name:N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide
CAS No.:1599475-03-2
Molecular Formula:C₁₉H₁₄F₂N₄OS₂
Molecular Weight:416.475
Hs Code.:

Synonyms:N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

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Chemical Property of N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

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Technology Process of N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

There total 4 articles about N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1599475-26-9
C₈H₁₀BN₃O₂S

: 1599475-28-1
C₁₁H₆BrF₂NOS

: 1599475-03-2
N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; acetonitrile; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1599475-25-8
C₈H₉N₃S

: 1599475-03-2
N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 6 h / -78 °C

1.2: -78 - 20 °C

1.3: 0.5 h

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 1599475-27-0
C₁₃H₈BrF₂NO₂S

: 1599475-03-2
N-(2,6-difluorophenyl)-5-(1-ethyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol; tetrahydrofuran / 0.5 h / 20 °C

2: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;