Technology Process of 1-(12,12,12-trifluorododecyl)cyclohexanol
There total 5 articles about 1-(12,12,12-trifluorododecyl)cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-12,12,12-dtrifluorododecane;
With
lithium;
In
diethyl ether;
for 1h;
cyclohexanone;
In
diethyl ether;
at 20 ℃;
DOI:10.1021/ja990719a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 95 percent / Raney Ni (W-2) / methanol / 20 h / 80 °C
2.1: 94 percent / Zn; NiCl2*6H2O / tetrahydrofuran; H2O / 3 h / 20 °C
3.1: 99 percent / LiAlH4 / diethyl ether / 5 h / 20 °C
4.1: 99 percent / 48 percent aq. HBr; H2SO4 / 5 h / 135 °C
5.1: Li / diethyl ether / 1 h
5.2: 40 percent / diethyl ether / 20 °C
With
lithium aluminium tetrahydride; Raney Ni (W-2); sulfuric acid; hydrogen bromide; lithium; nickel dichloride; zinc;
In
tetrahydrofuran; methanol; diethyl ether; water;
1.1: Addition / 2.1: Dehalogenation / 3.1: Reduction / 4.1: Bromination / 5.1: Metallation / 5.2: Alkylation;
DOI:10.1021/ja990719a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 94 percent / Zn; NiCl2*6H2O / tetrahydrofuran; H2O / 3 h / 20 °C
2.1: 99 percent / LiAlH4 / diethyl ether / 5 h / 20 °C
3.1: 99 percent / 48 percent aq. HBr; H2SO4 / 5 h / 135 °C
4.1: Li / diethyl ether / 1 h
4.2: 40 percent / diethyl ether / 20 °C
With
lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; lithium; nickel dichloride; zinc;
In
tetrahydrofuran; diethyl ether; water;
1.1: Dehalogenation / 2.1: Reduction / 3.1: Bromination / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/ja990719a
