cis-2,6-Dimethylmorpholine

Base Information

• Chemical Name: cis-2,6-Dimethylmorpholine
• CAS No.: 6485-55-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Hs Code.: 29339900
• European Community (EC) Number: 229-353-0
• UNII: VWD860P007
• DSSTox Substance ID: DTXSID00896844
• Nikkaji Number: J225.149C
• Mol file: 6485-55-8.mol

Synonyms:cis-2,6-Dimethylmorpholine;6485-55-8;(2R,6S)-2,6-dimethylmorpholine;(2S,6R)-2,6-dimethylmorpholine;Morpholine, 2,6-dimethyl-, cis-;2,6-Dimethylmorpholine, cis-;2,6-cis-dimethylmorpholine;MORPHOLINE, 2,6-DIMETHYL-, (2R,6S)-REL-;morpholine, 2,6-dimethyl-, (2R,6S)-;UNII-VWD860P007;VWD860P007;EINECS 229-353-0;EC 229-353-0;10025-23-7;MFCD00078428;2098200-15-6;CDMM;cis2,6-dimethylmorpholine;cis-2,6-Dimethylmorphine;2,6-cis-dimethylmorpholin;cis-2,6-dimethylmorpholin;cis-2,6-dimethymorpholine;cis-2,6-Dimethylmorpoline;cis 2,6-dimethylmorpholine;cis-2,6 dimethylmorpholine;Cic-2,6-Dimethylmorpholine;cis-2,6 dimethyl morpholine;cis-2,6-dimethyl morpholine;cis-2,6-dimethyl-morpholine;SCHEMBL73455;(Z)-2,6-Dimethylmorpholine;BIDD:GT0355;(cis)-2,6-dimethylmorpholine;2alpha,6alpha-Dimethylmorpholine;DTXSID00896844;(2r, 6s)-2,6-dimethylmorpholine;(2R,6S)-2,6-dimethyl-morpholine;AKOS006238146;2,6-DIMETHYLMORPHOLINE, MESO-;AC-1984;cis-2,6-Dimethylmorpholine, AldrichCPR;AS-10974;BF 421-10;AM20100586;CS-0008437;D0746;EN300-107440;W-104815;Q27292052;F0001-2361;Z1203730781

Chemical Property of cis-2,6-Dimethylmorpholine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 4.6mmHg at 25°C
• Melting Point: -85 °C
• Refractive Index: 1.445-1.447
• Boiling Point: 146.6 °C at 760 mmHg
• PKA: 9.04±0.60(Predicted)
• Flash Point: 48.9 °C
• PSA: 21.26000
• Density: 0.862 g/cm³
• LogP: 0.71200
• Storage Temp.: Flammables area
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 66.9

Purity/Quality:

99% ^*data from raw suppliers

cis-2,6-Dimethylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 34-21/22-10-41-37/38-22
• Safety Statements: 45-36/37/39-26-23-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CNCC(O1)C
• Isomeric SMILES: C[C@@H]1CNC[C@@H](O1)C
• Uses: cis-2,6-Dimethylmorphine is used in the synthesis of p38α MAP kinase inhibitors used in the treatment of autoimmune diseases. Also used towards the synthesis of potent agonists and antagonists of 5-HT 4 receptors.

Technology Process of cis-2,6-Dimethylmorpholine

There total 17 articles about cis-2,6-Dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

cis-2,6-dimethylmorpholine propionate → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

With sodium hydroxide; pH=14; Reagent/catalyst;

Reference yield: 80.0%

2,6-dimethyl morpholine (141-91-3) → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

2,6-dimethyl morpholine; With acetic acid; In ethyl acetate; at -2 - 40 ℃;

With sodium hydroxide; pH=14; Reagent/catalyst; Solvent; Temperature;

Reference yield: 80.0%

C6H11NO2 → (2S,6S)-2,6-Dimethyl-morpholin-3-one (117465-51-7) + cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

upstream raw materials:

2,6-dimethyl morpholine

diisopropanolamine

Downstream raw materials:

fenpropimorph

2,3,3,4,5,5,6-Heptafluoro-2,6-bis-trifluoromethyl-morpholine

1-ethoxy-perfluoropropane

bis(perfluoroisopropyl) ether

Refernces

• 1、 -. "Preparation method of high-purity cis-2,6-dimethylmorpholine". Paragraph 0035-0050. . Retrieved 2020/08/22.
• 2、 -. "2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION". . . Retrieved 2008/06/13.