9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene

Base Information

• Chemical Name: 9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene
• CAS No.: 1391824-63-7
• Molecular Formula: C₁₁H₂₂
• Molecular Weight: 158.261
• Mol file: 1391824-63-7.mol

Synonyms:9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene

Chemical Property of 9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene

There total 1 articles about 9-(⁽¹³⁾C-trideuteriomethyl)-2,6-dimethylnon-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[13C2H3] methyl iodide (20710-47-8,207507-22-0) + (S)-citronellyl bromide (10340-84-8,4895-14-1,58800-75-2,143615-81-0) → 9-((13)C-trideuteriomethyl)-2,6-dimethylnon-2-ene (1391824-63-7)

Guidance literature:

[13C₂H₃] methyl iodide; With magnesium; In diethyl ether; at 30 ℃; for 1h; Inert atmosphere;

(S)-citronellyl bromide; With copper(l) chloride; lithium chloride; In tetrahydrofuran; at 0 - 25 ℃; for 0.75h; Inert atmosphere;

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/jlcr.2916

Reference yield:

9-((13)C-trideuteriomethyl)-2,6-dimethylnon-2-ene (1391824-63-7) → 7-((13)C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one (1391824-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 h / 0 - 20 °C

2: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: lithium chloride / 18 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; water; acetone;

DOI:10.1002/jlcr.2916

Reference yield:

9-((13)C-trideuteriomethyl)-2,6-dimethylnon-2-ene (1391824-63-7) → 8-((13)C-trideuteriomethyl)-(3S)-tert-butyl 5-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)octanoate (1391824-66-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: chromium(VI) oxide; sulfuric acid / water; acetone / 20 h / 0 - 20 °C

2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: lithium chloride / 18 h / 20 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

4.2: 20 h / -70 - 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; water; acetone;

DOI:10.1002/jlcr.2916

upstream raw materials:

[13C₂H₃] methyl iodide

(S)-citronellyl bromide

Downstream raw materials:

7-(⁽¹³⁾C-trideuteriomethyl)-(4R,5S)-4-methyl-3-[4-methylheptanoyl]-5-phenyloxazolidin-2-one

8-(⁽¹³⁾C-trideuteriomethyl)-(3S)-tert-butyl 5-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)octanoate