ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

Base Information

Chemical Name:ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate
CAS No.:1339939-34-2
Molecular Formula:C₂₄H₂₇NO₅S
Molecular Weight:441.548
Hs Code.:

Synonyms:ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

Suppliers and Price of ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

There total 3 articles about ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1339939-33-1
ethyl 5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

: 63160-12-3,64705-27-7,73844-93-6
2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine

: 1339939-34-2
ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

: C₃₀H₃₁NO₇S₂

Guidance literature:: ethyl 5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.333333h; Inert atmosphere;

2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; In tetrahydrofuran; toluene; at -78 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.094

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1339939-34-2
ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

: C₃₀H₃₁NO₇S₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / 4 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: copper(I) thiophenolate / tetrahydrofuran / 1 h / -40 - 0 °C / Inert atmosphere

3.2: 2 h / -40 - 20 °C / Inert atmosphere

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.33 h / -78 °C / Inert atmosphere

4.2: 0.33 h / -78 °C / Inert atmosphere

With dmap; copper(I) thiophenolate; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In tetrahydrofuran; toluene; acetonitrile; 2.2: Horner-Wadsworth-Emmons olefination / 3.2: Michael condensation;
DOI:10.1016/j.tet.2011.08.094

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1339939-34-2
ethyl 2-hydroxy-5-methyl-3-[1-(4-toluenesulfonyl)indol-3-yl]hex-4-enoate

: C₃₀H₃₁NO₇S₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / 4 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: copper(I) thiophenolate / tetrahydrofuran / 1 h / -40 - 0 °C / Inert atmosphere

3.2: 2 h / -40 - 20 °C / Inert atmosphere

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.33 h / -78 °C / Inert atmosphere

4.2: 0.33 h / -78 °C / Inert atmosphere

With dmap; copper(I) thiophenolate; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In tetrahydrofuran; toluene; acetonitrile; 2.2: Horner-Wadsworth-Emmons olefination / 3.2: Michael condensation;
DOI:10.1016/j.tet.2011.08.094