methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

Base Information

Chemical Name:methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate
CAS No.:701294-97-5
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:

Synonyms:methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

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Chemical Property of methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

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Technology Process of methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

There total 7 articles about methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 701979-39-7
2-(methoxycarbonyl)-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionic acid

: 701294-97-5
methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

Guidance literature:: 2-(methoxycarbonyl)-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionic acid; With thionyl chloride; In benzene; at 20 - 80 ℃; for 1.5h;

With ammonia; In water; at 20 ℃; for 0.5h;

Reference yield:

: 1125-78-6
5,6,7,8-Tetrahydro-2-naphthol

: 701294-97-5
methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / ethanol / Heating

2: piperidinium acetate / toluene / Heating

3: H₂ / Pd/C / 20 °C

4: aq. NaOH / 20 °C

5: SOCl₂

6: aq. NH₃

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; piperdinium acetate; palladium on activated charcoal; In ethanol; toluene; 2: Knoevenagel condensation / 6: Schotten-Baumann reaction;
DOI:10.1016/j.bmcl.2004.04.053

Reference yield:

: 52191-15-8
4-(2-bromoethyloxy)benzaldehyde

: 701294-97-5
methyl 2-carbamoyl-3-[4-[2-(5,6,7,8-tetrahydro-2-naphthoxy)ethoxy]phenyl]propionate

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / ethanol / Heating

2: piperidinium acetate / toluene / Heating

3: H₂ / Pd/C / 20 °C

4: aq. NaOH / 20 °C

5: SOCl₂

6: aq. NH₃

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; thionyl chloride; hydrogen; piperdinium acetate; palladium on activated charcoal; In ethanol; toluene; 2: Knoevenagel condensation / 6: Schotten-Baumann reaction;
DOI:10.1016/j.bmcl.2004.04.053