(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one

Base Information

• Chemical Name: (S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one
• CAS No.: 914672-61-0
• Molecular Formula: C₂₃H₂₂ClFN₂O₄S
• Molecular Weight: 476.956

Synonyms:(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one

Chemical Property of (S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one

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Technology Process of (S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one

There total 1 articles about (S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C8H5Cl2NO2S + C15H18FNO2 (914672-51-8) → (S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one (914672-61-0)

Guidance literature:

C₁₅H₁₈FNO₂; With sodium hydride; In tetrahydrofuran; for 0.166667h;

C₈H₅Cl₂NO₂S; In tetrahydrofuran; for 1h;

Reference yield: 59.0%

(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one (914672-61-0) + methanesulfonamide (3144-09-0) → N-{3-[(S)-5-tert-butyl-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-7-ylmethyl}-methanesulfonamidee

Guidance literature:

(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methanesulfonamide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 40.5%

(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one (914672-61-0) → {3-[(S)-5-tert-Butyl-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-7-yl}-methanesulfonamide

Guidance literature:

(S)-5-tert-butyl-3-(7-chloromethyl-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yl)-1-(4-fluoro-benzyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one; With sodium 3-methoxy-3-oxo-propane-1-sulfinate; In dimethyl sulfoxide; at 20 ℃;

With sodium methylate; In methanol; dimethyl sulfoxide; at 20 ℃; for 0.166667h;

With sodium acetate; hydroxylamine-O-sulfonic acid; In methanol; water; dimethyl sulfoxide; for 1h;

upstream raw materials:

C₁₅H₁₈FNO₂

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