ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

Base Information

Chemical Name:ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate
CAS No.:1073546-35-6
Molecular Formula:C₃₃H₃₉FO₄
Molecular Weight:518.669
Hs Code.:

Synonyms:ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

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Chemical Property of ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

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Technology Process of ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

There total 6 articles about ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1073546-33-4
(S,E)-ethyl 3-(4-hydroxy-2-methylphenyl)hex-4-enoate

: 1073544-88-3
5-(chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 1073546-35-6
ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 19h;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073546-35-6
ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: thionyl chloride / dichloromethane / 16 h / 23 °C

4: caesium carbonate / N,N-dimethyl-formamide / 19 h / 23 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1073546-35-6
ethyl (3S,4E)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-2-methylphenyl)-4-hexenoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: thionyl chloride / dichloromethane / 16 h / 23 °C

4: caesium carbonate / N,N-dimethyl-formamide / 19 h / 23 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;