methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

Base Information

Chemical Name:methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide
CAS No.:74615-04-6
Molecular Formula:C₂₄H₂₆N₂O₆
Molecular Weight:438.48
Hs Code.:

Synonyms:methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

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Chemical Property of methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

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Technology Process of methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

There total 17 articles about methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74615-01-3
methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate

: 74615-04-6
methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: pertrifluoroacetic acid, Na₂HPO₄ / CH₂Cl₂

2: 10 percent / aq. KMnO₄ / acetone / 3 h

3: 1.) triethylamine, diphenylphosphoryl azide, 2.) water / 1.) benzene, reflux, 1 h, 2.) reflux, 30 min

With potassium permanganate; disodium hydrogenphosphate; diphenylphosphoranyl azide; water; triethylamine; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1021/ja00366a028

Reference yield:

: 74615-02-4
methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

: 74615-04-6
methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 10 percent / aq. KMnO₄ / acetone / 3 h

2: 1.) triethylamine, diphenylphosphoryl azide, 2.) water / 1.) benzene, reflux, 1 h, 2.) reflux, 30 min

With potassium permanganate; diphenylphosphoranyl azide; water; triethylamine; In acetone;
DOI:10.1021/ja00366a028

Reference yield:

: 74614-99-6
methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

: 74615-04-6
methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylsulfoxide / 120 h / 45 °C

2: potassium tert-butoxide / dimethylsulfoxide; tetrahydrofuran / 0.17 h / -12 °C

3: aq. oxalic acid / tetrahydrofuran / 1 h / Heating

4: pertrifluoroacetic acid, Na₂HPO₄ / CH₂Cl₂

5: 10 percent / aq. KMnO₄ / acetone / 3 h

6: 1.) triethylamine, diphenylphosphoryl azide, 2.) water / 1.) benzene, reflux, 1 h, 2.) reflux, 30 min

With potassium permanganate; disodium hydrogenphosphate; diphenylphosphoranyl azide; potassium tert-butylate; water; oxalic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/ja00366a028