isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

Base Information

Chemical Name:isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate
CAS No.:1404312-71-5
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:

Synonyms:isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

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Chemical Property of isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

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Technology Process of isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

There total 3 articles about isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1404312-52-2
diisopropyl 2-oxo-4-phenylpentanedioate

: 555-96-4
Benzylhydrazine

: 1404312-71-5
isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

Guidance literature:: With acetic acid; In dichloromethane; for 18h; Reflux;
DOI:10.1002/ejoc.201200734

Reference yield:

: 1404312-50-0
diisopropyl (E)-4-oxopent-2-enedioate

: 1404312-71-5
isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: [(Pd(μ-Cl)(κ(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; potassium phosphate / toluene / 18 h / 20 °C

2: acetic acid / dichloromethane / 18 h / Reflux

With potassium phosphate; [(Pd(μ-Cl)(κ(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; acetic acid; In dichloromethane; toluene;
DOI:10.1002/ejoc.201200734

Reference yield:

: 328-50-7
α-ketoglutaric acid

: 1404312-71-5
isopropyl 1-benzyl-6-oxo-5-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

2.1: bromine / dichloromethane / 3 h / Reflux

2.2: 0.5 h / 20 °C

3.1: [(Pd(μ-Cl)(κ(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; potassium phosphate / toluene / 18 h / 20 °C

4.1: acetic acid / dichloromethane / 18 h / Reflux

With potassium phosphate; [(Pd(μ-Cl)(κ(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; bromine; toluene-4-sulfonic acid; acetic acid; In dichloromethane; toluene;
DOI:10.1002/ejoc.201200734