(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

Base Information

Chemical Name:(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine
CAS No.:1373524-28-7
Molecular Formula:C₃₀H₂₈FN₃O₂S
Molecular Weight:513.636
Hs Code.:

Synonyms:(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

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Chemical Property of (3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

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Technology Process of (3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

There total 6 articles about (3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373524-22-1
(3S)-N-{1-[(5-Chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine

: 768-35-4
3-fluorophenylboronic acid

: 1373524-28-7
(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 100 ℃; for 3h; Inert atmosphere; capped vial;

Reference yield:

: 1373525-67-7
(S)-benzyl 3-((1-(tert-butoxycarbonyl)azetidin-3-yl)amino)pyrrolidine-1-carboxylate

: 1373524-28-7
(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h / 2068.65 Torr

2: triethylamine; HATU / dichloromethane / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

4: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C

5: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 3 h / 100 °C / Inert atmosphere; capped vial

With hydrogenchloride; potassium phosphate; hydrogen; triethylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In 1,4-dioxane; methanol; ethanol; dichloromethane; tert-butyl alcohol;

Reference yield:

: 50451-84-8
5-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid

: 1373524-28-7
(3S)-N-(1-{[5-(3-Fluorophenyl)-3-methyl-1-benzothiophen-2-yl]carbonyl}azetidin-3-yl)-1-(phenylcarbonyl)pyrrolidin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C

3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 3 h / 100 °C / Inert atmosphere; capped vial

With potassium phosphate; oxalyl dichloride; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; XPhos; In dichloromethane; tert-butyl alcohol;