((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester
• CAS No.: 188779-50-2
• Molecular Formula: C₂₂H₂₈N₄O₇
• Molecular Weight: 460.487

Synonyms:((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

Chemical Property of ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

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Technology Process of ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester

There total 2 articles about ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-(2-Hydroxyethyl)-glycine tert-butyl ester (66937-71-1) + [4-(4-Methoxybenzoylamino)-2-oxo-1,2-dihydropyrimidin-1-yl]acetic acid (172405-10-6) → ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester (188779-50-2)

Guidance literature:

With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(97)01044-2

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester (188779-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / N,N-diisopropylethylamine / dimethylformamide / 24 h / Ambient temperature

2: 66 percent / TOTU, NEt₃ / dimethylformamide / 4 h / Ambient temperature

With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(97)01044-2

Reference yield: 53.0%

((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid tert-butyl ester (188779-50-2) → ((2-Hydroxy-ethyl)-{2-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-acetyl}-amino)-acetic acid

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(97)01044-2

upstream raw materials:

N-(2-Hydroxyethyl)-glycine tert-butyl ester

[4-(4-Methoxybenzoylamino)-2-oxo-1,2-dihydropyrimidin-1-yl]acetic acid

bromoacetic acid tert-butyl ester

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