(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

Base Information

Chemical Name:(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one
CAS No.:163127-85-3
Molecular Formula:C₂₁H₂₄BrNO₃Si
Molecular Weight:446.416
Hs Code.:

Synonyms:(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

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Chemical Property of (4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

Chemical Property:

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Technology Process of (4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

There total 8 articles about (4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₂BNO₃Si

: 163127-85-3
(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1016/S0957-4166(01)00028-3

Reference yield:

: 59344-04-6
methyl 3-[(dimethyl)phenylsilyl]propionate

: 163127-85-3
(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / aq. LiOH / tetrahydrofuran / 15 h / 23 °C

2: NaH / tetrahydrofuran / 2 h / 0 °C

3: 1.04 g / BuLi / hexane; tetrahydrofuran / 3.5 h / -78 - 23 °C

4: DIPEA / CH₂Cl₂ / 4 h / -78 - 0 °C

5: 0.91 g / NBS / CH₂Cl₂ / 2 h / -78 °C

With lithium hydroxide; N-Bromosuccinimide; n-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0957-4166(01)00028-3

Reference yield:

: 17872-96-7
3-[(dimethyl)phenylsilyl]propionic acid

: 163127-85-3
(4R,2'S)-4-benzyl-3-{2-bromo-3-[(dimethyl)phenylsilyl]propionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 2 h / 0 °C

2: 1.04 g / BuLi / hexane; tetrahydrofuran / 3.5 h / -78 - 23 °C

3: DIPEA / CH₂Cl₂ / 4 h / -78 - 0 °C

4: 0.91 g / NBS / CH₂Cl₂ / 2 h / -78 °C

With N-Bromosuccinimide; n-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0957-4166(01)00028-3