1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid
CAS No.:1127364-04-8
Molecular Formula:C₂₃H₂₅N₅O₄S
Molecular Weight:467.549
Hs Code.:

Synonyms:1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

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Chemical Property of 1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

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Technology Process of 1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

There total 3 articles about 1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1127364-09-3
ethyl 1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylate

: 1127364-04-8
1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 4h; Reflux;
DOI:10.1021/acs.jmedchem.8b00393

Reference yield:

: 380430-57-9
4-(methylsulfonylamino)phenyl boronic acid

: 1127364-04-8
1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; propan-1-ol; water / 8 h / 100 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 110 - 120 °C

3: lithium hydroxide / water; tetrahydrofuran / 4 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; propan-1-ol; water; toluene; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.8b00393

Reference yield:

: 1056636-13-5
N-(4-(2-chloropyrimidin-4-yl)phenyl)methanesulfonamide

: 1127364-04-8
1-(4-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)phenyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 110 - 120 °C

2: lithium hydroxide / water; tetrahydrofuran / 4 h / Reflux

With toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acs.jmedchem.8b00393