2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide

Base Information

• Chemical Name: 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide
• CAS No.: 470704-95-1
• Molecular Formula: C₂₅H₃₇N₅O₄S
• Molecular Weight: 503.666
• Mol file: 470704-95-1.mol

Synonyms:2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide

Chemical Property of 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide

There total 2 articles about 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-dibenzylamino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide (470704-94-0) → 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide (470704-95-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm049454n

Reference yield:

2-Mercapto-benzothiazole-6-sulfonic acid ((2R,3S)-3-dibenzylamino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide → 2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide (470704-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm049454n

Reference yield: 67.0%

2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide (470704-95-1) + 1-[[[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl]oxy]pyrrolidine-2,5-dione (253265-97-3) → ((1S,2R)-1-Benzyl-3-{[2-(2-dimethylamino-ethylamino)-benzooxazole-6-sulfonyl]-isobutyl-amino}-2-hydroxy-propyl)-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm049454n

upstream raw materials:

2-(2-Dimethylamino-ethylamino)-benzooxazole-6-sulfonic acid ((2R,3S)-3-dibenzylamino-2-hydroxy-4-phenyl-butyl)-isobutyl-amide