3,4,5-Trimethoxyamphetamine, (R)-

Base Information

• Chemical Name: 3,4,5-Trimethoxyamphetamine, (R)-
• CAS No.: 64778-77-4
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.288
• UNII: P5003777YG
• Wikidata: Q27286181

Synonyms:3,4,5-Trimethoxyamphetamine, (R)-;UNII-P5003777YG;P5003777YG;64778-77-4;Benzeneethanamine, 3,4,5-trimethoxy-alpha-methyl-, (alphaR)-;SCHEMBL394374;(R)-3,4,5-trimethoxyamphetamine;TMA (PSYCHEDELIC), (R)-;Q27286181;BENZENEETHANAMINE, 3,4,5-TRIMETHOXY-.ALPHA.-METHYL-, (.ALPHA.R)-

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Chemical Property of 3,4,5-Trimethoxyamphetamine, (R)-

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 225.13649347
• Heavy Atom Count: 16
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C(=C1)OC)OC)OC)N
• Isomeric SMILES: C[C@H](CC1=CC(=C(C(=C1)OC)OC)OC)N

Technology Process of 3,4,5-Trimethoxyamphetamine, (R)-

There total 4 articles about 3,4,5-Trimethoxyamphetamine, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-1-Methyl-2-(3,4,5-trimethoxy-phenyl)-ethyl]-((R)-1-phenyl-ethyl)-amine; hydrochloride → (-)-3-(3,4,5-Trimethoxyphenyl)-isopropylamin (64778-77-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00263a013

Reference yield:

{(S)-1-[(R)-1-Methyl-2-(3,4,5-trimethoxy-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester → (-)-3-(3,4,5-Trimethoxyphenyl)-isopropylamin (64778-77-4)

Guidance literature:

Multistep reaction; (i) H₂, Pd-C, (ii) PhNCS, (iii) CF₃CO₂H;

DOI:10.1021/jm00256a016

Reference yield:

3,4,5-trimethoxyamphetamine (1082-88-8) → (-)-3-(3,4,5-Trimethoxyphenyl)-isopropylamin (64778-77-4)

Guidance literature:

Multi-step reaction with 2 steps

2: (i) H₂, Pd-C, (ii) PhNCS, (iii) CF₃CO₂H

DOI:10.1021/jm00256a016

upstream raw materials:

3,4,5-trimethoxyamphetamine