2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1363144-17-5
Molecular Formula:C₂₀H₁₅F₂N₃O₃
Molecular Weight:383.354
Hs Code.:

Synonyms:2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

There total 1 articles about 2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363144-11-9
N'-[(3,4-difluorophenyl)acetyl]-3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide

: 1363144-17-5
2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: With triphenylphosphine; In tetrachloromethane; water; ethyl acetate; acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 1363144-06-2
tert-butyl[2-chloro-1-(iodomethyl)ethoxy]dimethylsilane

: 1363144-17-5
2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

: 1363144-23-3
(6RS,8SR)-6-{[tert-butyl(dimethyl)silyl]oxy}-8-(3,4-difluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: 2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

tert-butyl[2-chloro-1-(iodomethyl)ethoxy]dimethylsilane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 2h;

Reference yield:

: 1363144-17-5
2-(3,4-difluorobenzyl)-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

: 1363134-50-2
(6RS,8RS)-8-(3,4-difluorophenyl)-8-(hydroxymethyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 0.5 h / 20 °C

1.3: diphenylphosphino-polystyrene / 2 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 0.17 h / 0 °C

2.2: 1 h / 20 °C

2.3: 0.25 h / 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;