2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine

Base Information

• Chemical Name: 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine
• CAS No.: 1184962-24-0
• Molecular Formula: C₂₄H₁₉N₅OS
• Molecular Weight: 425.514
• Mol file: 1184962-24-0.mol

Synonyms:2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine

Chemical Property of 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine

There total 4 articles about 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbonyl]-N-phenylhydrazinecarbothioamide → 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine (1184962-24-0)

Guidance literature:

With sulfuric acid; for 4h; Cooling with ice;

DOI:10.1016/j.ejmech.2018.11.067

Reference yield: 71.0%

C24H21N5OS (1184962-16-0) → 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine (1184962-24-0)

Guidance literature:

With iron(III) chloride; In ethanol; water; at 70 - 80 ℃; for 1.5h;

DOI:10.1002/jccs.200800196

Reference yield:

phenyl isothiocyanate (103-72-0) → 2-{3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl}-N-phenyl-1,3,4-thiadiazol-5-amine (1184962-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 4 h / Reflux

2: sulfuric acid / 4 h / Cooling with ice

With sulfuric acid; In ethanol;

DOI:10.1016/j.ejmech.2018.11.067

upstream raw materials:

C₂₄H₂₁N₅OS

phenyl isothiocyanate