5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

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Chemical Name:5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine
CAS No.:1397693-13-8
Molecular Formula:C₂₁H₂₈N₈O₂
Molecular Weight:424.506
Hs Code.:

Synonyms:5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

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Chemical Property of 5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

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Technology Process of 5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

There total 4 articles about 5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1397693-18-3
5-(3'-hydroxypropyloxy)-6-ethyl-2,4-diaminopyrimidine

: 5-(4'-hydroxyphenyl)-6-ethylpyrimidine-2,4-diamine

: 1397693-13-8
5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00389

Reference yield:

: 838-96-0
2-[4-(benzyloxy)phenyl]acetonitrile

: 1397693-13-8
5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / -78 - 90 °C / Inert atmosphere

1.2: 0.33 h / 90 °C / Inert atmosphere

2.1: diazomethane / methanol; 1,4-dioxane / 8 h / 20 °C

2.2: 6 h / 90 - 100 °C / Inert atmosphere

3.1: palladium 10% on activated carbon / methanol; 1,4-dioxane; cyclohexene / 6 h / 65 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With diazomethane; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; sodium hydride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil; cyclohexene; 4.1: |Mitsunobu Displacement;
DOI:10.1021/acsmedchemlett.8b00389

Reference yield:

: 2-(4-(benzyloxy)phenyl)-3-oxopentanenitrile

: 1397693-13-8
5-[4-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]phenyl]-6-ethylpyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diazomethane / methanol; 1,4-dioxane / 8 h / 20 °C

1.2: 6 h / 90 - 100 °C / Inert atmosphere

2.1: palladium 10% on activated carbon / methanol; 1,4-dioxane; cyclohexene / 6 h / 65 °C / Inert atmosphere

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

With diazomethane; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; cyclohexene; 3.1: |Mitsunobu Displacement;
DOI:10.1021/acsmedchemlett.8b00389