6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

Base Information

Chemical Name:6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one
CAS No.:1256780-47-8
Molecular Formula:C₃₁H₅₂N₂O₃Si
Molecular Weight:528.851
Hs Code.:

Synonyms:6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

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Chemical Property of 6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

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Technology Process of 6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

There total 3 articles about 6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.3%

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 1256780-33-2
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

: 1256780-45-6
4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-6-(2-methoxyethoxy)-2-methylpyrimidine

: 1256780-47-8
6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 9h; Inert atmosphere;

Reference yield:

: 161922-06-1
4-(bromomethyl-2,6-diisopropylphenoxy)(tert-butyl)dimethylsilane

: 1256780-45-6
4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-6-(2-methoxyethoxy)-2-methylpyrimidine

: 1256780-47-8
6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: sodium methylate / methanol / 6 h / Reflux

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 9 h / 20 °C / Inert atmosphere

With sodium methylate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil; 3.1: Mitsunobu reaction;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-45-6
4-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-6-(2-methoxyethoxy)-2-methylpyrimidine

: 1256780-47-8
6-butyl-3-(2-methoxyethoxy)-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: sodium methylate / methanol / 6 h / Reflux

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 9 h / 20 °C / Inert atmosphere

With sodium methylate; phosphorus tribromide; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: Mitsunobu reaction;