1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone
• CAS No.: 146753-52-8
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 146753-52-8.mol

Synonyms:1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone

Chemical Property of 1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone

There total 1 articles about 1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone (1835-02-5) → 1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone (146753-52-8)

Guidance literature:

With potassium carbonate; In benzene; for 24h; Heating;

DOI:10.1248/cpb.40.2543

Reference yield: 92.0%

1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone (146753-52-8) → α-(3,4-dimethoxyphenyl)-3,4-dihydro-1(2H)-quinolineethanol (146400-46-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 24h; Ambient temperature;

DOI:10.1248/cpb.40.2543

Reference yield:

1-(3,4-dimethoxyphenyl)-2-(1,2,3,4-tetrahydro-1-quinolinyl)ethanone (146753-52-8) → 1-(3,4-dimethoxyphenyl)-3,4-dihydro-2-(1H)-quinolinone (146400-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / NaBH₄ / ethanol / 24 h / Ambient temperature

2: 70 percent / EDTA, Hg(OAc)2 / H₂O; acetic acid / 1.5 h / 110 - 120 °C

3: 81 percent / 70percent aq. HClO₄, H₂ / 10percent Pd/C / ethanol / 10 h / 45 °C / 1520 - 3800 Torr

With sodium tetrahydroborate; perchloric acid; ethylenediaminetetraacetic acid; mercury(II) diacetate; hydrogen; palladium on activated charcoal; In ethanol; water; acetic acid;

DOI:10.1248/cpb.40.2543

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

α-(3,4-dimethoxyphenyl)-3,4-dihydro-1(2H)-quinolineethanol

1-(3,4-dimethoxyphenyl)-3,4-dihydro-2-(1H)-quinolinone

1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3,4-dihydro-2(1H)-quinolinone