N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

Base Information

Chemical Name:N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid
CAS No.:894803-11-3
Molecular Formula:C₄₁H₅₅N₇O₁₃
Molecular Weight:853.927
Hs Code.:

N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

Synonyms:N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

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Chemical Property of N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

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Technology Process of N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

There total 4 articles about N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 894803-10-2
tert-butoxycarbonyl-L-leucine 4-(7-amino-1H-quinolin-2-on-4-yl)methylanilide

: 23911-26-4
diethylenetriaminepentaacetic dianhydride

: 894803-11-3
N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1021/ja060729t

Reference yield:

: 748806-78-2
7-(9-fluorenylmethoxycarbonylamino)-4-(4-nitrobenzyl)-1H-quinolin-2-one

: 894803-11-3
N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / iron / ethanol; acetic acid / 2 h / Heating

2: 67 percent / HBTU; HOBT*H₂O; DIEA / dimethylformamide / 2 h / 20 °C

3: 76 percent / piperidine / dimethylformamide / 1 h / 20 °C

4: 53 percent / triethylamine / dimethylformamide / 2 h / 0 °C

With piperidine; iron; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja060729t

Reference yield:

: 748806-79-3
4-(4-aminobenzyl)-7-(9-fluorenylmethoxycarbonylamino)-1H-quinolin-2-one

: 894803-11-3
N-{N-[4-(tert-butoxycarbonyl-L-leucyl)aminobenzyl-1,2-dihydro-2-oxoquinolin-7-yl]carbamoylmethyl}-N,N',N'',N''-diethylenetriaminetetraacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / HBTU; HOBT*H₂O; DIEA / dimethylformamide / 2 h / 20 °C

2: 76 percent / piperidine / dimethylformamide / 1 h / 20 °C

3: 53 percent / triethylamine / dimethylformamide / 2 h / 0 °C

With piperidine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja060729t