N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine

Base Information

• Chemical Name: N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine
• CAS No.: 132343-99-8
• Molecular Formula: C₂₄H₂₆F₃N₉O₆
• Molecular Weight: 593.522

Synonyms:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine

Chemical Property of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine

Chemical Property:

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Technology Process of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine

There total 1 articles about N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-(carboxymethyl)-N^δ-(trifluoroacetyl)-L-ornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) + (S)-2-Amino-5-[carboxymethyl-(2,2,2-trifluoro-acetyl)-amino]-pentanoic acid; hydrochloride (132344-03-7) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-(carboxymethyl)-Nδ-(trifluoroacetyl)-L-ornithine (132343-99-8)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00108a032

Reference yield: 49.0%

Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-(carboxymethyl)-Nδ-(trifluoroacetyl)-L-ornithine (132343-99-8) → (S)-5-(Carboxymethyl-amino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid; compound with trifluoro-acetic acid (132344-01-5)

Guidance literature:

With ammonium hydroxide; at 25 ℃; for 24h;

DOI:10.1021/jm00108a032

upstream raw materials:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

(S)-2-Amino-5-[carboxymethyl-(2,2,2-trifluoro-acetyl)-amino]-pentanoic acid; hydrochloride

Downstream raw materials:

(S)-5-(Carboxymethyl-amino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid; compound with trifluoro-acetic acid

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