Technology Process of 1-acetyl-5,5-dibenzyl-4-methylpyrrolidin-2-one
There total 6 articles about 1-acetyl-5,5-dibenzyl-4-methylpyrrolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: MeNH2*HCl, AcOK, trimethyl orthoformate / methanol / 16 h / Heating
2: NaBH4 / dimethylsulfoxide / 1 h / 20 °C
3: 63.4 percent / tetrabutylammonium chloride, KF*2H2O / dimethylformamide / 50 h / 60 °C
4: 93.1 percent / 1.) Zn powder; 2.) 15percent aq. TiCl3 / acetic acid / 1.) r.t, 25 min, then 70 deg C, 35 min; 2.) r.t., 40 min
5: 89.2 percent / cc. H2SO4 / 6.5 h / 110 °C
With
potassium fluoride; sodium tetrahydroborate; titanium(III) chloride; sulfuric acid; tetrabutyl-ammonium chloride; methylamine hydrochloride; potassium acetate; zinc; trimethyl orthoformate;
In
methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19870002027
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaBH4 / dimethylsulfoxide / 1 h / 20 °C
2: 63.4 percent / tetrabutylammonium chloride, KF*2H2O / dimethylformamide / 50 h / 60 °C
3: 93.1 percent / 1.) Zn powder; 2.) 15percent aq. TiCl3 / acetic acid / 1.) r.t, 25 min, then 70 deg C, 35 min; 2.) r.t., 40 min
4: 89.2 percent / cc. H2SO4 / 6.5 h / 110 °C
With
potassium fluoride; sodium tetrahydroborate; titanium(III) chloride; sulfuric acid; tetrabutyl-ammonium chloride; zinc;
In
acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19870002027
