(S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile

Base Information

• Chemical Name: (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile
• CAS No.: 1307310-18-4
• Molecular Formula: C₂₇H₄₀N₂O
• Molecular Weight: 408.627
• Mol file: 1307310-18-4.mol

Synonyms:(S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile

Chemical Property of (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile

There total 12 articles about (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H34O2 (1307310-19-5) + (S)-pyrrolidine-2-carbonitrile trifluoroacetic acid salt → (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile (1307310-18-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm2001053

Reference yield:

4-(9-cyclohexylnonyl)benzaldehyde (1307310-17-3) → (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile (1307310-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1: Pinnick oxidation;

DOI:10.1021/jm2001053

Reference yield:

non-8-en-1-ylcyclohexane (183598-36-9) → (S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-carbonitrile (1307310-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 20 °C

1.2: 16 h

2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1.2: Suzuki coupling / 2.1: Pinnick oxidation;

DOI:10.1021/jm2001053

upstream raw materials:

C₂₂H₃₄O₂

non-8-en-1-ylcyclohexane

4-(9-cyclohexylnonyl)benzaldehyde

1-(tert-butoxycarbonyl)-L-proline

Downstream raw materials:

VPC₁₄₃v47