1-phenyl-3-(p-tolyl)but-2-en-1-one

Base Information

• Chemical Name: 1-phenyl-3-(p-tolyl)but-2-en-1-one
• CAS No.: 14161-83-2
• Molecular Formula: C₁₇H₁₆O
• Molecular Weight: 236.313
• Mol file: 14161-83-2.mol

Synonyms:1-phenyl-3-(p-tolyl)but-2-en-1-one

Chemical Property of 1-phenyl-3-(p-tolyl)but-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-(p-tolyl)but-2-en-1-one

There total 5 articles about 1-phenyl-3-(p-tolyl)but-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17NO2 → 1-phenyl-3-(p-tolyl)but-2-en-1-one (14161-83-2)

Guidance literature:

With phenyl metal salt; In tetrahydrofuran; at -30 - 0 ℃;

DOI:10.1021/acs.orglett.9b03365

Reference yield:

ethyl 3-(4-methylphenyl)-2-butenoate (94853-53-9,115819-11-9,6305-61-9) → 1-phenyl-3-(p-tolyl)but-2-en-1-one (14161-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: diethyl ether / Heating

With sodium hydroxide; In diethyl ether;

DOI:10.1021/jo01286a047

Reference yield:

para-methylacetophenone (122-00-9) → 1-phenyl-3-(p-tolyl)but-2-en-1-one (14161-83-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 25 °C

2.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / -10 - 5 °C / Inert atmosphere

3.1: phenyl metal salt / tetrahydrofuran / -30 - 0 °C

With isopropylmagnesium bromide; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1021/acs.orglett.9b03365

upstream raw materials:

β-methyl 4-methylphenylacrylic acid

phenyllithium

ethyl 3-(4-methylphenyl)-2-butenoate

para-methylacetophenone