ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

Base Information

Chemical Name:ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate
CAS No.:155953-72-3
Molecular Formula:C₇H₉F₃O₂
Molecular Weight:182.142
Hs Code.:

Synonyms:ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

Chemical Property:

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Technology Process of ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

There total 1 articles about ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-26-6
ethyl 4,4,4-trifluorobutanoate

: 155953-72-3
ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) diisopropylamine, butyllithium / 1.) THF, hexanes, -78 deg C, 30 min, 2.) THF, hexanes, from -78 deg C to RT

2: 1.1 g / zinc bromide / CH₂Cl₂ / 20 h / Ambient temperature

3: sodium metaperiodate / methanol; H₂O / 0 - 24 °C

4: hexane / Heating

With sodium periodate; n-butyllithium; diisopropylamine; zinc dibromide; In methanol; hexane; dichloromethane; water;
DOI:10.1021/jm00035a008

Reference yield:

: 155953-72-3
ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

: 1028282-09-8
3-Methoxy-4-[1-methyl-5-(4,4,4-trifluoro-2-methylene-butylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL-H / diethyl ether

2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature

3: hydrazine monohydrate / ethanol / 1 h / Heating

4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

5: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / Ambient temperature

With dmap; lithium hydroxide; diisobutylaluminium hydride; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00035a008

Reference yield:

: 155953-72-3
ethyl 2-(2,2,2-trifluoroethyl)-2-propenoate

: 1026535-88-5
3-Methoxy-4-[1-methyl-5-(4,4,4-trifluoro-2-methylene-butylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DIBAL-H / diethyl ether

2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature

3: hydrazine monohydrate / ethanol / 1 h / Heating

4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With dmap; diisobutylaluminium hydride; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00035a008