(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

Base Information

Chemical Name:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium
CAS No.:1583283-15-1
Molecular Formula:C₂₀H₃₃N₃O₅P*Li
Molecular Weight:433.414
Hs Code.:

Synonyms:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

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Chemical Property of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

Chemical Property:

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Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

There total 9 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1583283-62-8
C₂₁H₃₆N₃O₅P

: 1583283-15-1
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

Guidance literature:: With lithium hydroxide; In water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 621-84-1
O-benzyl carbamate

: 1583283-15-1
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate; water / water / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: 3 h / Reflux

4: sodium hydroxide / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

6: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 31037-42-0
hydroxymethyl carbamic acid benzyl ester

: 1583283-15-1
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-pentylpentanamide lithium

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: 3 h / Reflux

3: sodium hydroxide / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

5: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a