1-[(3R)-5-(3-azabicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea

Base Information

Chemical Name:1-[(3R)-5-(3-azabicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea
CAS No.:154967-59-6
Molecular Formula:C₂₆H₃₁N₅O₂
Molecular Weight:445.564
Hs Code.:

Synonyms:1H-1,4-Benzodiazepine,urea deriv.; Azabicyclo[3.2.2]nonane, urea deriv.; L 741545

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Chemical Property of 1-[(3R)-5-(3-azabicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea

Chemical Property:

Density:1.32g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[(3R)-5-(3-azabicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea

There total 9 articles about 1-[(3R)-5-(3-azabicyclo[3.2.2]non-3-yl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154851-43-1
5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-1H-benzo[e][1,4]diazepine-2,3-dione 3-oxime

: 154967-59-6
(-)-N-[5-(3-azabicyclo[3.2.2]nonan-3-yl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-methylphenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N / tetrahydrofuran / 3 h / Heating

2: H₂ / 10percent Pd/C / methanol / 3 h / 2585.7 Torr / Ambient temperature

3: tetrahydrofuran / room temperature 5 min, 4 deg C overnight

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1055/s-1994-25513

Reference yield:

: 154851-44-2
C₂₁H₂₇N₅O₃

: 154967-59-6
(-)-N-[5-(3-azabicyclo[3.2.2]nonan-3-yl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-methylphenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 3 h / 2585.7 Torr / Ambient temperature

2: tetrahydrofuran / room temperature 5 min, 4 deg C overnight

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1055/s-1994-25513

Reference yield:

: 85-91-6
Methyl N-methylanthranilate

: 154967-59-6
(-)-N-[5-(3-azabicyclo[3.2.2]nonan-3-yl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'-[3-methylphenyl]urea

Guidance literature:: Multi-step reaction with 8 steps

1: NaOH / H₂O; CH₂Cl₂

2: NH₃ / methanol

3: PCl₅ / CH₂Cl₂

4: NEt₃ / CH₂Cl₂

5: t-BuOK, isopentyl nitrite / toluene / -20 °C

6: Et₃N / tetrahydrofuran / 60 °C

7: H₂ / 10percent Pd/C / methanol / 2068.6 Torr / Ambient temperature

8: tetrahydrofuran

With sodium hydroxide; phosphorus pentachloride; potassium tert-butylate; ammonia; hydrogen; triethylamine; isopentyl nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; toluene;