Technology Process of 8,8-diphenyl-1,7-dioxaspiro[5.6]dodecane
There total 5 articles about 8,8-diphenyl-1,7-dioxaspiro[5.6]dodecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate;
In
pentane;
at -35 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/ja302704m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / -78 - 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.1: (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / pentane / 48 h / -35 °C / Inert atmosphere; Molecular sieve
With
(S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; tetrabutyl ammonium fluoride; tert.-butyl lithium;
In
tetrahydrofuran; pentane;
DOI:10.1021/ja302704m
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2: (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate / pentane / 48 h / -35 °C / Inert atmosphere; Molecular sieve
With
(S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; pentane;
DOI:10.1021/ja302704m
