(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Base Information

Chemical Name:(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone
CAS No.:1447731-99-8
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Suppliers and Price of (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

There total 3 articles about (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 603121-10-4
(2S,4E)-2,4-dimethyl-4-hexenal

: 1447731-99-8
(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 0 - 3 ℃; Inert atmosphere;

(2S,4E)-2,4-dimethyl-4-hexenal; In dichloromethane; at -65 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1021/ol3026457

Reference yield: 55.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 159254-36-1
(2R)-(E)-2,4-dimethyl-4-hexenal

: 1447731-99-8
(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; Inert atmosphere;

With triethylamine; In dichloromethane; for 0.5h; Inert atmosphere;

(2R)-(E)-2,4-dimethyl-4-hexenal; Further stages;
DOI:10.1016/j.tet.2013.06.012

Reference yield:

: (2R,4E)-methyl 2,4-dimethyl-hex-4-enoate

: 1447731-99-8
(2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

With di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1016/j.tet.2013.06.012