2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Base Information

Chemical Name:2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid
CAS No.:1421230-65-0
Molecular Formula:C₂₄H₁₇N₅O₂S
Molecular Weight:439.497
Hs Code.:

Synonyms:2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Suppliers and Price of 2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

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Chemical Property of 2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

There total 10 articles about 2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1421230-72-9
methyl 2-(4-(4-(4-(tert-butoxycarbonylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetate

: 1421230-65-0
2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Guidance literature:: methyl 2-(4-(4-(4-(tert-butoxycarbonylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

2-chloropyrimidine; With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1421230-73-0
C₂₁H₁₇N₃O₂S

: 1421230-65-0
2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Guidance literature:: 2-chloropyrimidine; C₂₁H₁₇N₃O₂S; With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1421230-65-0
2-(4-(4-(4-(pyrimidin-2-ylamino)phenyl)thieno[3,2-d]pyrimidin-7-yl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 2 h / Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; calcium acetate; tricyclohexylphosphine / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; calcium acetate; sodium carbonate; trifluoroacetic acid; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water;