(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Base Information

Chemical Name:(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide
CAS No.:1344707-04-5
Molecular Formula:C₂₃H₁₈F₃N₅O₅
Molecular Weight:501.422
Hs Code.:

Synonyms:(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Property of (R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Technology Process of (R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

There total 11 articles about (R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.03%

: 1344708-47-9
(R/S)-2-hydroxy-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 22356-89-4
glycine methylamide

: 1344707-04-5
(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1344707-04-5
(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 1.5 h / 20 °C

2.1: copper(l) iodide / N,N-dimethyl-formamide; N,N,N,N,N,N-hexamethylphosphoric triamide / 20 - 80 °C

3.1: water; lithium hydroxide monohydrate / methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h

5.2: 0.33 h

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.58 h

6.2: pH 5

7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; N-iodo-succinimide; copper(l) iodide; trifluoro-[1,3,5]triazine; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-74-3
phenylacetylene

: 1344707-04-5
(R/S)-2-hydroxy-N-(2-(methylamino)-2-oxoethyl)-2-(4-(5-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 1.5 h / 20 °C

3.1: copper(l) iodide / N,N-dimethyl-formamide; N,N,N,N,N,N-hexamethylphosphoric triamide / 20 - 80 °C

4.1: water; lithium hydroxide monohydrate / methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h

6.2: 0.33 h

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.58 h

7.2: pH 5

8.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; N-iodo-succinimide; copper(l) iodide; trifluoro-[1,3,5]triazine; lithium hydroxide monohydrate; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;