N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester

Base Information

• Chemical Name: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester
• CAS No.: 1185198-39-3
• Molecular Formula: C₂₇H₃₃ClN₆O₄S
• Molecular Weight: 573.116

Synonyms:N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester

Chemical Property of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester

Chemical Property:

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Technology Process of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester

There total 2 articles about N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L?methionine benzyl ester p?toluenesulfonate (68739-90-2) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester (1185198-39-3)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L?methionine benzyl ester p?toluenesulfonate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.333333h; pH=9;

In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmc.2009.07.035

Reference yield:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + methionine benzyl ester (63649-07-0) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester (1185198-39-3)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

methionine benzyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmcl.2009.05.077

Reference yield: 96.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-methionine benzyl ester (1185198-39-3) → N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-methionine benzyl ester (1185198-59-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2009.07.035

upstream raw materials:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine

methionine benzyl ester

L?methionine benzyl ester p?toluenesulfonate

Downstream raw materials:

N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-methionine benzyl ester

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