1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

Base Information

Chemical Name:1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine
CAS No.:908337-67-7
Molecular Formula:C₂₄H₂₀F₂N₂O₇
Molecular Weight:486.429
Hs Code.:

Synonyms:1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

Suppliers and Price of 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

There total 5 articles about 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908337-63-3
2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

: 65-71-4,28806-14-6,691841-57-3
thymin

: 908337-67-7
1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

Guidance literature:: thymin; With 1,1,1,3,3,3-hexamethyl-disilazane; chloro-trimethyl-silane; In acetonitrile; at 110 - 120 ℃; for 5 - 6h;

2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 90 ℃; for 5h;

With water; In dichloromethane; acetonitrile;

Reference yield:

: 134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 908337-67-7
1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-D-erythro-pentofuranos-1-yl)thymine

Guidance literature:: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose; 2,4-bis(trimethylsiloxy)-5-methylpyrimidine; With trimethylsilyl trifluoromethanesulfonate; In 1,1-dichloroethane; at 90 - 100 ℃; for 10h; Inert atmosphere;

With sodium hydrogencarbonate; In 1,1-dichloroethane; water; at 20 ℃;
DOI:10.1016/j.bmc.2011.05.037

Reference yield:

: 1173824-58-2,143157-25-9,143157-22-6
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate

: 908337-67-7
1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine

: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-D-erythro-pentofuranos-1-yl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere

2.2: 20 °C

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In 1,1-dichloroethane; dichloromethane;
DOI:10.1016/j.bmc.2011.05.037