methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

Base Information

Chemical Name:methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate
CAS No.:618881-41-7
Molecular Formula:C₂₅H₂₉NO₃
Molecular Weight:391.51
Hs Code.:

Synonyms:methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

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Chemical Property of methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

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Technology Process of methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

There total 6 articles about methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 103-63-9
1-phenyl-2-bromoethane

: 618881-40-6
methyl [3-formyl-2-pentyl-5-methyl]indole-6-carboxylate

: 618881-41-7
methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 19.5h;
DOI:10.1021/ja035540l

Reference yield:

: 18595-12-5
methyl 5-amino-2-methylbenzoate

: 618881-41-7
methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 34 percent / iodomonochloride; calcium carbonate / CH₂Cl₂; methanol; H₂O / 20 °C

2.1: diethylamine; dichlorobis(triphenylphosphino)palladium; copper iodide / dimethylformamide / 2 h / 20 °C

3.1: 3.4 mg / dichlorobis(benzonitrile)palladium / dimethylformamide / 0.5 h / 80 °C

4.1: phosphorous oxychloride / 0.5 h / 5 °C

4.2: 99 percent / 0.83 h / 5 °C

5.1: 44 percent / cesium carbonate / dimethylformamide / 19.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; Iodine monochloride; caesium carbonate; diethylamine; calcium carbonate; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja035540l

Reference yield:

: 77324-87-9
methyl 2-methyl-5-nitrobenzoate

: 618881-41-7
methyl [3-formyl-2-pentyl-1-(2-phenylethyl)-5-methyl]indole-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / Pd/C; H₂ / methanol / 2 h / 20 °C

2.1: 34 percent / iodomonochloride; calcium carbonate / CH₂Cl₂; methanol; H₂O / 20 °C

3.1: diethylamine; dichlorobis(triphenylphosphino)palladium; copper iodide / dimethylformamide / 2 h / 20 °C

4.1: 3.4 mg / dichlorobis(benzonitrile)palladium / dimethylformamide / 0.5 h / 80 °C

5.1: phosphorous oxychloride / 0.5 h / 5 °C

5.2: 99 percent / 0.83 h / 5 °C

6.1: 44 percent / cesium carbonate / dimethylformamide / 19.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; hydrogen; Iodine monochloride; caesium carbonate; diethylamine; calcium carbonate; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja035540l