2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde

Base Information

• Chemical Name: 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde
• CAS No.: 244128-27-6
• Molecular Formula: C₁₇H₁₂BrNO₂
• Molecular Weight: 342.192
• Mol file: 244128-27-6.mol

Synonyms:2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde

Chemical Property of 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde

There total 10 articles about 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C17H14BrNO2 (946075-36-1) → 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde (244128-27-6)

Guidance literature:

With dipyridinium dichromate; In dichloromethane;

DOI:10.1016/j.bmcl.2007.04.064

Reference yield: 87.0%

4-bromo-3-<2-(dibromomethyl)phenyl>-2-methyl-1(2H)-isoquinolinone (244128-26-5) → 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde (244128-27-6)

Guidance literature:

With water; dimethyl sulfoxide; calcium carbonate; Heating;

DOI:10.1248/cpb.47.900

Reference yield:

N,2-dimethylbenzamide (2170-09-4) → 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde (244128-27-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) N-BuLi / 1.) -50 deg C

2: 1.) NaH / 1.) THF, 0 deg C, 1 h , 2.) THF, 2 h

3: 64 percent / Br₂, NaHCO₃ / CCl₄ / 1 h / 50 °C / Irradiation

4: 87 percent / CaCO₃, H₂O, DMSO / Heating

With n-butyllithium; water; bromine; sodium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; calcium carbonate; In tetrachloromethane;

DOI:10.1248/cpb.47.900

upstream raw materials:

4-bromo-3-<2-(dibromomethyl)phenyl>-2-methyl-1(2H)-isoquinolinone

C₁₇H₁₄BrNO₂

3-[2-(4-methoxybenzyloxymethyl)phenyl]-2H-isoquinolin-1-one

C₂₅H₂₂BrNO₃

Downstream raw materials:

4-bromo-2-methyl-3-(2-vinylphenyl)-1(2H)-isoquinolinone